De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling

@inproceedings{Vecchio2014DeDifferentiationCM,
  title={De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling},
  author={Catherine A. Del Vecchio and Yuxiong Feng and Ethan S. Sokol and Erik J. Tillman and Sandhya Sanduja and Ferenc Reinhardt and Piyush B. Gupta},
  booktitle={PLoS biology},
  year={2014}
}
Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug resistant (MDR). De-differentiated cancer cells acquire MDR by up-regulating reactive oxygen species (ROS)-scavenging enzymes and drug efflux pumps, but how these genes are up-regulated in response to de-differentiation is not known. Here, we examine this question by using global transcriptional profiling to identify ROS-induced genes that are already up-regulated in de-differentiated cells, even in… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 9 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Coordinating Organismal Physiology Through the Unfolded Protein Response

Current Topics in Microbiology and Immunology • 2018
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 69 references

Similar Papers

Loading similar papers…