DdrO is an essential protein that regulates the radiation desiccation response and the apoptotic-like cell death in the radioresistant Deinococcus radiodurans bacterium.

@article{Devigne2015DdrOIA,
  title={DdrO is an essential protein that regulates the radiation desiccation response and the apoptotic-like cell death in the radioresistant Deinococcus radiodurans bacterium.},
  author={Alice Devigne and Solenne Ithurbide and Claire Bouthier de la Tour and Fanny Marie Passot and Martine Mathieu and Suzanne Sommer and Pascale Servant},
  journal={Molecular microbiology},
  year={2015},
  volume={96 5},
  pages={1069-84}
}
Deinococcus radiodurans is known for its extreme radioresistance. Comparative genomics identified a radiation-desiccation response (RDR) regulon comprising genes that are highly induced after DNA damage and containing a conserved motif (RDRM) upstream of their coding region. We demonstrated that the RDRM sequence is involved in cis-regulation of the RDR gene ddrB in vivo. Using a transposon mutagenesis approach, we showed that, in addition to ddrO encoding a predicted RDR repressor and irrE… CONTINUE READING
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