Ddi1-like protein from Leishmania major is an active aspartyl proteinase

  title={Ddi1-like protein from Leishmania major is an active aspartyl proteinase},
  author={Mar{\'i}a Jes{\'u}s Perteguer and Paulino G{\'o}mez-Puertas and Carmen Ca{\~n}avate and Francehuli Dagger and Ter{\'e}sa Garate and Elizabeth Valdivieso},
  journal={Cell Stress and Chaperones},
Eukaryotic cells respond to DNA damage by activating damage checkpoint pathways, which arrest cell cycle progression and induce gene expression. We isolated a full-length cDNA encoding a 49-kDa protein from Leishmania major, which exhibited significant deduced amino acid sequence homology with the annotated Leishmania sp. DNA damage-inducible (Ddi1-like) protein, as well as with the Ddi1 protein from Saccharomyces cerevisiae. In contrast to the previously described Ddi1 protein, the protein… CONTINUE READING


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