DdNek2, the first non-vertebrate homologue of human Nek2, is involved in the formation of microtubule-organizing centers.

@article{Graef2002DdNek2TF,
  title={DdNek2, the first non-vertebrate homologue of human Nek2, is involved in the formation of microtubule-organizing centers.},
  author={Ralph Oliver Graef},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 9},
  pages={
          1919-29
        }
}
Dictyostelium Nek2 (DdNek2) is the first structural and functional non-vertebrate homologue of human Nek2, a NIMA-related serine/threonine kinase required for centrosome splitting in early mitosis. DdNek2 shares 43% overall amino-acid identity with its human counterpart and 54% identity within the catalytic domain. Both proteins can be subdivided in an N-terminal catalytic domain, a leucine zipper and a C-terminal domain. Kinase assays with bacterially expressed DdNek2 and C-terminal deletion… CONTINUE READING

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