Dcsbis (PA2771) from Pseudomonas aeruginosa is a highly active diguanylate cyclase with unique activity regulation

@inproceedings{Chen2016DcsbisF,
  title={Dcsbis (PA2771) from Pseudomonas aeruginosa is a highly active diguanylate cyclase with unique activity regulation},
  author={Ying Chen and Shiheng Liu and Cuilan Liu and Yan Tang Huang and Kaikai Chi and Tiantian Su and Deyu Zhu and Jin Peng and Zhijie Xia and Jing He and Sujuan Xu and Wei Hu and Lichuan Gu},
  booktitle={Scientific reports},
  year={2016}
}
C-di-GMP (3',5' -Cyclic diguanylic acid) is an important second messenger in bacteria that influences virulence, motility, biofilm formation, and cell division. The level of c-di-GMP in cells is controlled by diguanyl cyclases (DGCs) and phosphodiesterases (PDEs). Here, we report the biochemical functions and crystal structure of the potential diguanylase Dcsbis (PA2771, a diguanylate cyclase with a self-blocked I-site) from Pseudomonas aeruginosa PAO1. The full-length Dcsbis protein contains… CONTINUE READING
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