DcpS is a transcript-specific modulator of RNA in mammalian cells.

  title={DcpS is a transcript-specific modulator of RNA in mammalian cells.},
  author={Mi Zhou and Sophie Bail and Heather L. Plasterer and James R. Rusche and Megerditch Kiledjian},
  volume={21 7},
The scavenger decapping enzyme DcpS is a multifunctional protein initially identified by its property to hydrolyze the resulting cap structure following 3' end mRNA decay. In Saccharomyces cerevisiae, the DcpS homolog Dcs1 is an obligate cofactor for the 5'-3' exoribonuclease Xrn1 while the Caenorhabditis elegans homolog Dcs-1, facilitates Xrn1 mediated microRNA turnover. In both cases, this function is independent of the decapping activity. Whether DcpS and its decapping activity can affect… CONTINUE READING
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