Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin.

@article{Wang2011Dcdc2KM,
  title={Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin.},
  author={Yan Wang and X Yin and Gabriela Ros{\'e}n and Lisa Gabel and Sarah M. Guadiana and Matthew R. Sarkisian and Albert M. Galaburda and Joseph J. Loturco},
  journal={Neuroscience},
  year={2011},
  volume={190},
  pages={398-408}
}
The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. Here we report the first phenotypic analysis of a Dcdc2 knockout mouse. Comparisons between Dcdc2 knockout mice and wild-type (wt) littermates revealed no significant differences in neuronal migration, neocortical lamination, neuronal cilliogenesis or dendritic differentiation. Considering previous studies showing genetic interactions and… CONTINUE READING