Dbest1, a Drosophila homolog of human Bestrophin, is not required for viability or photoreceptor integrity.

@article{Tavsanli2001Dbest1AD,
  title={Dbest1, a Drosophila homolog of human Bestrophin, is not required for viability or photoreceptor integrity.},
  author={Beril C. Tavsanli and Kartik S. Pappu and Sunil Q. Mehta and Graeme Mardon},
  journal={Genesis},
  year={2001},
  volume={31 3},
  pages={130-6}
}
Best macular dystrophy (BMD) is an autosomal dominant human disease characterized by macular degeneration with juvenile onset (OMIM 153700). The disease is most often associated with mutations in Bestrophin, which encodes a novel protein with four putative transmembrane domains. However, complete loss-of-function mutations in Bestrophin have not been reported in humans or mice. We have identified three homologs of human Bestrophin in the Drosophila genome (dbest1-3). The protein products of… CONTINUE READING