Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

  title={Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis},
  author={Xiaolu Yang and Roya Khosravi-Far and Howard Y Chang and David Baltimore},
The Fas cell surface receptor induces apoptosis upon receptor oligomerization. We have identified a novel signaling protein, termed Daxx, that binds specifically to the Fas death domain. Overexpression of Daxx enhances Fas-mediated apoptosis and activates the Jun N-terminal kinase (JNK) pathway. A C-terminal portion of Daxx interacts with the Fas death domain, while a different region activates both JNK and apoptosis. The Fas-binding domain of Daxx is a dominant-negative inhibitor of both Fas… CONTINUE READING
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