Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA.

@article{Kelly2010Dax1UO,
  title={Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA.},
  author={Victoria R. Kelly and Bin Xu and Rork Kuick and R. J. Koenig and Gary D Hammer},
  journal={Molecular endocrinology},
  year={2010},
  volume={24 12},
  pages={
          2281-91
        }
}
Dax1 (Nr0b1) is an atypical orphan nuclear receptor that has recently been shown to play a role in mouse embryonic stem (mES) cell pluripotency. Here we describe a mechanism by which Dax1 maintains pluripotency. In steroidogenic cells, Dax1 protein interacts with the NR5A nuclear receptor steroidogenic factor 1 (Nr5a1) to inhibit transcription of target genes. In mES cells, liver receptor homolog 1 (LRH-1, Nr5a2), the other NR5A family member, is expressed, and LRH-1 has been shown to interact… CONTINUE READING
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