Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells.

@article{Sun2009Dax1BT,
  title={Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells.},
  author={Chuanhai Sun and Yuhki Nakatake and Tadayuki Akagi and Hiroki Ura and Takahiko Matsuda and Akira Nishiyama and Hiroshi Koide and Minoru S. H. Ko and Hitoshi Niwa and Takashi Yokota},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 16},
  pages={4574-83}
}
Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of blastocysts. Transcription factor Oct3/4 is an indispensable factor in the self-renewal of ES cells. In this study, we searched for a protein that would interact with Oct3/4 in ES cells and identified an orphan nuclear hormone receptor, Dax1. The association of Dax1 with Oct3/4 was mediated through the POU-specific domain of Oct3/4. Ectopic expression of Dax1 inhibited Oct3/4-mediated activation of an artificial… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Similar Papers

Loading similar papers…