Dax-1 knockdown in mouse embryonic stem cells induces loss of pluripotency and multilineage differentiation.

Abstract

Dax-1 (Nr0b1) is an orphan member of the nuclear hormone receptor superfamily that has a key role in adrenogonadal development and function. Recent studies have also implicated Dax-1 in the transcriptional network controlling embryonic stem (ES) cell pluripotency. Here, we show that Dax-1 expression is affected by differentiating treatments and… (More)
DOI: 10.1002/stem.78

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