David Arthur John Tyrrell. 19 June 1925 — 2 May 2005

@article{Kerr2007DavidAJ,
  title={David Arthur John Tyrrell. 19 June 1925 — 2 May 2005},
  author={J. R. Kerr and D. Taylor-Robinson},
  journal={Biographical Memoirs of Fellows of the Royal Society},
  year={2007},
  pages={349 - 363}
}
David Tyrrell is remembered by physicians and scientists principally for his discovery of the common cold viruses and elucidation of their pathogenesis, but also for his work in various other areas, including influenza, bovine spongiform encephalopathy (BSE) and chronic fatigue syndrome (CFS). David possessed a deep humanity, honesty, perseverance and a vision of collaboration as a means of making discoveries that would contribute meaningfully to the alleviation of human suffering. He also had… Expand
1 Citations
Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis.
TLDR
Clustering of quantitative polymerase chain reaction data from patients with CFS/ME revealed 7 subtypes with distinct differences in Medical Outcomes Survey Short Form-36 scores, clinical phenotypes, and severity. Expand

References

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POSSIBLE VIRUS IN SCHIZOPHRENIA AND SOME NEUROLOGICAL DISORDERS
TLDR
Cerebrospinal fluid from 13 of 38 patients with schizophrenia had a cytopathic effect in cultures of MRC5 cells and the agent could not be propagated serially in a satisfactory manner but its properties were those of a virus. Expand
Experimental parvoviral infection in humans.
TLDR
The hematologic changes associated with infection support the hypothesis that the same virus is responsible for the temporary arrest of erythropoiesis that leads to aplastic crisis in persons with chronic hemolytic anemia. Expand
CHARACTERISTICS OF PATIENTS WITH SCHIZOPHRENIA OR NEUROLOGICAL DISORDER AND VIRUS-LIKE AGENT IN CEREBROSPINAL FLUID
A virus-like agent (V.L.A.) with a cytopathic effect on cultured cells was found in the cerebrospinal fluid of 18 of 47 patients with schizophrenia, of whom 10 had nuclear schizophrenic symptoms. InExpand
Variation of erythroid and myeloid precursors in the marrow and peripheral blood of volunteer subjects infected with human parvovirus (B19).
TLDR
It is suggested that the architecture of the marrow might partially isolate progenitors from high titers of virus in the serum and individual variation in this respect might give the results observed. Expand
Circulating tumour necrosis factor-alpha and interferon-gamma are detectable during acute and convalescent parvovirus B19 infection and are associated with prolonged and chronic fatigue.
TLDR
Prolonged upregulation of serum IFN-gamma and TNF-alpha appears to represent a consistent host response to symptomatic B19 virus infection. Expand
Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome
TLDR
This results suggest that patients with CFS have reproducible alterations in gene regulation, and upregulation of neuropathy target esterase and eukaryotic translation initiation factor 4G1 may suggest links with organophosphate exposure and virus infection, respectively. Expand
The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis.
TLDR
It is demonstrated that upper respiratory viral infections are strongly associated in time with hospital admissions for asthma in children and adults and school attendance was found to be a major confounding variable in children. Expand
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children
TLDR
This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children. Expand
Studies on the pathogenicity for tissue cultures of some viruses isolated from common colds.
Experiments employing human volunteers
  • Lancet i, 235–237
  • 1960
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