Daunorubicin reduction mediated by aldehyde and ketone reductases.

Abstract

1. The cancer chemotherapeutic antibiotic, daunorubicin, is metabolized in rabbit liver by two distinct cytoplasmic reductases, with pH optima at 6.0 and 8.5. 2. A comparison of inhibition and activation of these two enzymes provides evidence of biochemical and kinetic differences, and suggests that the enzymes belong to different classes of carbonyl… (More)

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Cite this paper

@article{Ahmed1981DaunorubicinRM, title={Daunorubicin reduction mediated by aldehyde and ketone reductases.}, author={Nisar Ahmed and Ronald L. Felsted and Nicholas R. Bachur}, journal={Xenobiotica; the fate of foreign compounds in biological systems}, year={1981}, volume={11 2}, pages={131-6} }