Daunorubicin-induced variations in gene transcription: commitment to proliferation arrest, senescence and apoptosis.

@article{Mansilla2003DaunorubicininducedVI,
  title={Daunorubicin-induced variations in gene transcription: commitment to proliferation arrest, senescence and apoptosis.},
  author={Sylvia Mansilla and B. Pi{\~n}a and J. Portugal},
  journal={The Biochemical journal},
  year={2003},
  volume={372 Pt 3},
  pages={
          703-11
        }
}
We used a human cDNA macroarray containing various oncogenes and tumour suppressor genes to assess gene expression profiles in early-passage Jurkat T lymphocytes treated with clinically relevant concentrations of the antitumour antibiotic daunorubicin. Several oncogenes and tumour suppressor genes were either up- or down-regulated depending on the daunorubicin concentration used. The expression levels of some of these genes were confirmed by semi-quantitative reverse transcriptase-PCR. We also… Expand
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