Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.

  title={Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.},
  author={J P Jaffr{\'e}zou and Thierry Levade and Ali Betta{\"i}eb and N Andrieu and Christine Bezombes and Nicolas Maestre and Sabine Anne Vermeersch and Aline Rousse and Guy Laurent},
  journal={The EMBO journal},
  volume={15 10},
The nature of the signaling pathway(s) which initiate drug-triggered apoptosis remains largely unknown and is of fundamental importance in understanding cell death induced by chemotherapeutic agents. Here we show that in the leukemic cell lines U937 and HL-60, daunorubicin, at concentrations which trigger apoptosis, stimulated two distinct cycles of sphingomyelin hydrolysis (approximately 20% decrease at 1 microM) within 4-10 min and 60-75 min with concomitant ceramide generation. We… CONTINUE READING

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