Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation.

@article{Srinivasan2010DaunorubicinEI,
  title={Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation.},
  author={Padmanabhan Srinivasan and Sankara Naynar Palani and Ranjan Prasad},
  journal={FEMS microbiology letters},
  year={2010},
  volume={305 1},
  pages={18-27}
}
Streptomyces peucetius self-resistance genes drrA and drrB encode membrane-associated proteins that function like an ABC transporter for the efflux of daunorubicin and to maintain a constant subinhibitory physiological concentration of the drug within the cell. In this study, the drrA and drrB operons were disrupted for investigating drug production, self-resistance and regulation. The drrA-drrB null mutant was highly sensitive to daunorubicin. A 10-fold decrease in drug production was observed… CONTINUE READING