Daunomycin. I. The Structure of Daunomycinone

  title={Daunomycin. I. The Structure of Daunomycinone},
  author={Federico Arcamone and Giovanni Franceschi and Piergiuseppe Orezzi and Giuseppe Cassinelli and W. Barbieri and Rosanna. Mondelli},
  journal={Journal of the American Chemical Society},
Antineoplastic and Immunomodulating Agents (L)
  • A. Kleemann
  • Medicine
    Ullmann's Encyclopedia of Industrial Chemistry
  • 2022
Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids
An orienting mechanistic evaluation revealed that the daunorubicin hybrid inhibits the ability of human topoisomerase IIα to relax negatively and positively supercoiled DNA.
Pathway engineering of anthracyclines: Blazing trails in natural product glycodiversification.
This Synopsis considers recent advances in glycosyltransferase structural biology and site-directed mutagenesis, pathway engineering, and deoxysugar combinatorial biosynthesis with a focus on generation of "new-to-nature" anthracycline analogs.
Antitumour Anthracyclines: Progress and Perspectives
This review covers the most clinically relevant anthracyclines and their development over decades, since the first discovered natural prototypes to recent semisynthetic and synthetic derivatives.
The Roots of Modern Oncology: From Discovery of New Antitumor Anthracyclines to their Clinical Use
The Milan scene in the 1960s, a city admired and noted for the outstanding scientific achievements of its private and public institutions in drugs and industrial product discovery, is reviewed, with a pioneering and fruitful example of a translational discovery program with relevant transatlantic connections.
Underexplored Opportunities for Natural Products in Drug Discovery.
  • B. Decorte
  • Biology
    Journal of medicinal chemistry
  • 2016
In this Perspective, examples of natural product derived marketed drugs with therapeutic utility in clinical space that is different from the biological profile of the starting material are presented, demonstrating that this is not merely a theoretical concept but both a clinical reality and an underexplored opportunity.
Electrochemical control of reversible DNA hybridisation : for future use in nucleic acid amplification
The difference in the stability of duplex DNA, as a direct result of the redox-state of daunomycin, was exploited to drive cyclic electrochemically controlled DNA denaturation and renaturation under isothermal conditions.