Daunomycin in the treatment of experimental proliferative vitreoretinopathy. Effective doses in vitro and in vivo.

@article{Wiedemann1985DaunomycinIT,
  title={Daunomycin in the treatment of experimental proliferative vitreoretinopathy. Effective doses in vitro and in vivo.},
  author={Peter Wiedemann and Nino Sorgente and C Bekhor and Randi Patterson and Tai Tien Tran and Stephen J. Ryan},
  journal={Investigative ophthalmology & visual science},
  year={1985},
  volume={26 5},
  pages={719-25}
}
In previous studies the authors have shown that daunomycin, an anthracycline antibiotic, when injected into the vitreous effectively controls experimental proliferative vitreoretinopathy. Here we show that by administering daunomycin intravitreally it is possible to achieve in vivo concentrations that prevent fibroblast proliferation in vitro. The authors have also determined that the half-life of daunomycin in the vitreous is 131 min, indicating that a critical concentration is maintained in… CONTINUE READING