Dating the common ancestor of SIVcpz and HIV‐1 group M and the origin of HIV‐1 subtypes by using a new method to uncover clock‐like molecular evolution

  title={Dating the common ancestor of SIVcpz and HIV‐1 group M and the origin of HIV‐1 subtypes by using a new method to uncover clock‐like molecular evolution},
  author={Marco Salemi and Korbinian Strimmer and William W. Hall and Margaret Duffy and Eric Delaporte and Souleymane Mboup and Martine Peeters and Anne-Mieke Vandamme},
  journal={The FASEB Journal},
  pages={276 - 278}
Attempts to estimate the time of origin of human immunodeficiency virus (HIV)‐1 by using phylogenetic analysis are seriously flawed because of the unequal evolutionary rates among different viral lineages. Here, we report a new method of molecular clock analysis, called Site Stripping for Clock Detection (SSCD), which allows selection of nucleotide sites evolving at an equal rate in different lineages. The method was validated on a dataset of patients all infected with hepatitis C virus in 1977… 

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