Database on natural polymorphisms and resistance-related non-synonymous mutations in thymidine kinase and DNA polymerase genes of herpes simplex virus types 1 and 2.

@article{Sauerbrei2016DatabaseON,
  title={Database on natural polymorphisms and resistance-related non-synonymous mutations in thymidine kinase and DNA polymerase genes of herpes simplex virus types 1 and 2.},
  author={Andreas Sauerbrei and Kathrin Bohn-Wippert and Marisa Kaspar and Andi Krumbholz and Matthias Karrasch and Roland Zell},
  journal={The Journal of antimicrobial chemotherapy},
  year={2016},
  volume={71 1},
  pages={6-16}
}
The use of genotypic resistance testing of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) is increasing because the rapid availability of results significantly improves the treatment of severe infections, especially in immunocompromised patients. However, an essential precondition is a broad knowledge of natural polymorphisms and resistance-associated mutations in the thymidine kinase (TK) and DNA polymerase (pol) genes, of which the DNA polymerase (Pol) enzyme is targeted by the highly… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Viral Surveillance in Serum Samples From Patients With Acute Liver Failure By Metagenomic Next-Generation Sequencing

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2017
View 17 Excerpts
Highly Influenced

Optimal management of genital herpes: current perspectives

Infection and drug resistance • 2016
View 3 Excerpts

Similar Papers

Loading similar papers…