Database of genomic biomarkers for cancer drugs and clinical targetability in solid tumors.

@article{Dienstmann2015DatabaseOG,
  title={Database of genomic biomarkers for cancer drugs and clinical targetability in solid tumors.},
  author={Rodrigo Dienstmann and In Sock Jang and Brian M. Bot and Stephen H. Friend and Justin Guinney},
  journal={Cancer discovery},
  year={2015},
  volume={5 2},
  pages={118-23}
}
SUMMARY Comprehensive genomic profiling is expected to revolutionize cancer therapy. In this Prospective, we present the prevalence of mutations and copy-number alterations with predictive associations across solid tumors at different levels of stringency for gene-drug targetability. More than 90% of The Cancer Genome Atlas samples have potentially targetable alterations, the majority with multiple events, illustrating the challenges for treatment prioritization given the complexity of the… CONTINUE READING

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