Data mining of NCI's anticancer screening database reveals mitochondrial complex I inhibitors cytotoxic to leukemia cell lines.

@article{Glover2007DataMO,
  title={Data mining of NCI's anticancer screening database reveals mitochondrial complex I inhibitors cytotoxic to leukemia cell lines.},
  author={Constance J. Glover and Alfred A. Rabow and Yasemin G. Isgor and Robert H. Shoemaker and David G. Covell},
  journal={Biochemical pharmacology},
  year={2007},
  volume={73 3},
  pages={331-40}
}
Mitochondria are principal mediators of apoptosis and thus can be considered molecular targets for new chemotherapeutic agents in the treatment of cancer. Inhibitors of mitochondrial complex I of the electron transport chain have been shown to induce apoptosis and exhibit antitumor activity. In an effort to find novel complex I inhibitors which exhibited… CONTINUE READING