Data maximization by multipass analysis of protein mass spectra.

@article{Tharakan2010DataMB,
  title={Data maximization by multipass analysis of protein mass spectra.},
  author={Ravi Tharakan and Nathan Edwards and David R. Graham},
  journal={Proteomics},
  year={2010},
  volume={10 6},
  pages={1160-71}
}
With the proliferation of search engines for the analysis of MS data, multisearch techniques aimed at boosting the discriminating power of the search engines' score functions have recently become popular. Much statistical and algorithmic work has been done, therefore, in order to be able to combine and parse multiple search streams. However, multisearch techniques suffer from long run times, and may have little impact on false negatives because of similar peptide filtering heuristics between… CONTINUE READING

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