Data characterizing the biophysical and nitric oxide release properties of the tDodSNO – Styrene maleic anhydride nanoparticle SMA-tDodSNO

  title={Data characterizing the biophysical and nitric oxide release properties of the tDodSNO – Styrene maleic anhydride nanoparticle SMA-tDodSNO},
  author={Houman Alimoradi and Anita Barzegar-fallah and Ivan A Sammut and Khaled Greish and Gregory I. Giles},
  journal={Data in Brief},
  pages={1771 - 1775}
Nitric oxide (NO) donor drugs have a range of clinical applications, and are also being developed as therapeutics for the potential treatment of multiple diseases. This article presents data describing the synthesis and characterisation of a novel NO releasing nanoparticle formed by encapsulation of the NO donor tDodSNO into a co-polymer of styrene and maleic acid (SMA) to afford SMA-tDodSNO. The pharmacological activity of SMA-tDodSNO is discussed in our accompanying manuscript “Encapsulation… Expand
2 Citations
Controlled Delivery of Nitric Oxide for Cancer Therapy
The effects of NO in cancer biology, NO releasing moieties which can be used for NO delivery, and current advances in the design of NO releasing biomaterials focusing on their applications for tumor therapy are covered. Expand


Encapsulation of tDodSNO generates a photoactivated nitric oxide releasing nanoparticle for localized control of vasodilation and vascular hyperpermeability
The NP was markedly superior as a photoactive NO donor in comparison to the S‐nitrosothiols GSNO and SNAP, which are commonly used in experimental studies, as well as sodium nitroprusside, a clinically used vasodilator. Expand
The Molecular Design of S‐Nitrosothiols as Photodynamic Agents for Controlled Nitric Oxide Release
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SMA-doxorubicin, a new polymeric micellar drug for effective targeting to solid tumours.
Data indicate that i.v. administration of SMA-Dox micellar formulation can enhance the therapeutic effect of doxorubicin while reducing greatly cardiac and bone marrow toxicity, which should allow safe use of high doses of this agent. Expand
Mixing artifacts from the bolus addition of nitric oxide to oxymyoglobin: implications for S-nitrosothiol formation.
It is demonstrated that bolus addition of NO to oxymyoglobin (oxyMb) results in the artifactual formation of nitrosating intermediates, and suggests that the presence of the NO/O(2) reaction is an artifact of bolus NO addition, and leads to the formation of Nitrite, or GSNO in the presenceof GSH. Expand
Synthesis, spectroscopic analysis and photolabilization of water-soluble ruthenium(III)-nitrosyl complexes.
The results indicate that neutral water is not a solvent that promotes the photodissociation of NO, which would present a major obstacle to the goal of designing {RuNO}(6) complexes as photolabile NO delivery agents in vivo. Expand
Methods in Nitric Oxide Research
This is a multi-author book that avoids many of the pitfalls of this genre and is a major resource for anyone involved in nitric oxide research and deserves a place on their laboratory and library bookshelves. Expand
Stamler, Methods in Nitric Oxide
  • 1996