Data assimilation constrains new connections and components in a complex, eukaryotic circadian clock model

@inproceedings{Pokhilko2010DataAC,
  title={Data assimilation constrains new connections and components in a complex, eukaryotic circadian clock model},
  author={Alexandra Pokhilko and Sarah K. Hodge and Kevin Stratford and Kirsten Knox and Kieron D. Edwards and Adrian W. Thomson and Takeshi Mizuno and Andrew J. Millar},
  booktitle={Molecular systems biology},
  year={2010}
}
Circadian clocks generate 24-h rhythms that are entrained by the day/night cycle. Clock circuits include several light inputs and interlocked feedback loops, with complex dynamics. Multiple biological components can contribute to each part of the circuit in higher organisms. Mechanistic models with morning, evening and central feedback loops have provided a heuristic framework for the clock in plants, but were based on transcriptional control. Here, we model observed, post-transcriptional and… CONTINUE READING
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