Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts

@inproceedings{Haubeiss2010DasatinibRC,
  title={Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts},
  author={Silke Haubeiss and Jens O. Schmid and Thomas E M{\"u}rdter and Maike Sonnenberg and Godehard Friedel and Heiko van der Kuip and Walter Erich Aulitzky},
  booktitle={Molecular Cancer},
  year={2010}
}
Cancer associated fibroblasts (CAFs) play a critical role for growth, invasion, and metastasis of cancer. Therefore, targeting CAFs with small molecule inhibitors may be an attractive anti-tumor strategy. The current study aims to identify small molecule kinase inhibitors affecting CAF's growth and to characterize the biological effects of active compounds on primary CAFs from lung cancer. We screened two individual CAF strains for their sensitivity to a panel of 160 kinase inhibitors. Five… CONTINUE READING