Dasatinib may also inhibit c-Kit in triple negative breast cancer cell lines

@article{Dizdar2007DasatinibMA,
  title={Dasatinib may also inhibit c-Kit in triple negative breast cancer cell lines},
  author={Omer Dizdar and Didem Şener Dede and Nilufer Bulut and Kadri Altundag},
  journal={Breast Cancer Research and Treatment},
  year={2007},
  volume={107},
  pages={303-303}
}
In their interesting paper, Finn et al. [1] reported that dasatinib selectively inhibits growth of basal-type/’’triplenegative’’ breast cancer cell lines growing in vitro. Authors discussed that this activity may be happened through the inhibition of src and/or bcl kinase. Interestingly, by using a panel of 21 basal-like tumors, Nielsen et al. [2] showed that triple-negative breast cancer cell was typically immunohistochemically negative for estrogen receptor and HER2 but positive for basal… CONTINUE READING