Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias.

  title={Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias.},
  author={Bella S. Guerrouahen and Muneyoshi Futami and Christos Vaklavas and Jukka A Kanerva and Zakary L. Whichard and Kenechi Nwawka and Elisabeth G. Blanchard and Francis Y. F. Lee and Lisa J. Robinson and Robert J. Arceci and Steven M. Kornblau and Eric Wieder and Yvon E. Cayre and Seth J Corey},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={16 4},
PURPOSE Dasatinib is a dual Src/Abl inhibitor recently approved for Bcr-Abl+ leukemias with resistance or intolerance to prior therapy. Because Src kinases contribute to multiple blood cell functions by triggering a variety of signaling pathways, we hypothesized that their molecular targeting might lead to growth inhibition in acute myeloid leukemia (AML). EXPERIMENTAL DESIGN We studied growth factor-dependent and growth factor-independent leukemic cell lines, including three cell lines… CONTINUE READING
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