Darwinian evolution in the genealogy of haemoglobin

  title={Darwinian evolution in the genealogy of haemoglobin},
  author={Morris Goodman and G. William Moore and Genji Matsuda},
Frequencies of mutations between reconstructed ancestor and descendant sequences of codons for metazoan globin chains show that natural selection guided protein evolution. Mutations which improved haemoglobin function were accepted at an accelerated rate in the first vertebrates. Rates decelerated after functional opportunities had been exploited. 
Silent nucleotide substitutions and the molecular evolutionary clock.
Half of the nucleotide substitutions during the evolutionary divergence of genes in animals, bacteria, and viruses are silent changes. These result from an inherent biochemical property of DNA and
Evolution of the Primary Structures of Primate and Other Vertebrate Hemoglobins
It is thought that these genes evolve through the process of mutation and natural selection, resulting in the diversity of organisms in the world.
Positive Darwinian selection after gene duplication in primate ribonuclease genes.
It was found that the number of arginine residues increased substantially in a short period of evolutionary time after gene duplication, and these amino acid changes probably produced the novel anti-pathogen function of ECP.
Molecular Evolution Above the Species Level: Branching Pattern, Rates, and Mechanisms
It is hypothesized that positive selection for differentiation of the chains produced by duplicated globin genes was responsible for greatly accelerated globin evolutionary rates, especially at sites acquiring cooperative functions, during the basal radiation of Gnathostomata and Tetrapoda.
Biomolecular evidence on human origins from the standpoint of Darwinian theory.
Analysis of the data from immunological and electrophoretic examination of proteins, amino acid sequencing, nuclear DNA hybridization, mitochondrial DNA comparisons, and chromosomal banding patterns
Nonuniform Molecular Divergence
This chapter considers the simplest changes in the primary structure of genes and their messenger RNA products caused by point mutation, the replacement of one nucleoside by another and fixation of that replacement by natural selection or by random drift.
Mammalian specific mouse genes are evolving faster than mouse genes conserved across other eukaryotic lineages.
It is shown that genes conserved in eukaryota, coelomata, and bilateria, that is, proteins that arose earlier in evolution as compared to mammalia specific genes evolve slowly and are subjected to negative selection, supporting the notion that evolutionary rates progressively diminish with the age of a gene.
Doubt about studies of globin evolution based on maximum parsimony codons and the augmentation procedure
  • M. Kimura
  • Biology
    Journal of Molecular Evolution
  • 2005
SummaryBoth the maximum parsimony method of codon assignment and the augmentation procedure, as used by Goodman and his associates, are liable to serious errors and therefore should not be used for


Molecular Evolution in the Descent of Man
Three computer programs applied to data from phylogenetic trees and protein polymorphism can be used to find the rate of molecular evolution of different species. It can be shown that this is slower
Amino-acid Sequences of Kangaroo Myoglobin and Haemoglobin and the Date of Marsupial-Eutherian Divergence
Differences in the amino-acid sequences of corresponding globin proteins have been used to calculate when marsupials and eutherians diverged in evolution.
Evolutionary Rate at the Molecular Level
Calculating the rate of evolution in terms of nucleotide substitutions seems to give a value so high that many of the mutations involved must be neutral ones.
Molecular Evolution of Myoglobin and the Fossil Record: a Phylogenetic Synthesis
An ancestral myoglobin chain has been deduced by comparing the differences in the amino acid sequences of eighteen living species and assessing from the fossil evidence the probable times of
Non-Darwinian evolution.
NonDarwinian evolution of protein and DNA, comparing expectations of evolution models for protein and amino acid changes
Studies on marsupial proteins. VI. Evolutionary changes of beta-globins of the macropodidae and the amino acid sequence of beta-globin from Potorous tridactylus.
Haemoglobins from 13 species of the subfamily Macropodinae and one species of the subfamily Potoroinae have been studied.
Studies on marsupial proteins. V. Amino acid sequence of the -chain of haemoglobin from the grey kangaroo, Macropus giganteus.
The amino acid sequence of the jS-chain of haemoglobin from M. giganteus has been determined and special procedures were necessary for three peptides which were insoluble.
On some principles governing molecular evolution.
  • M. Kimura, T. Ohta
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1974
Five Pillars of Evolution were culled from the accumulated evidence on molecular evolution and theoretical considerations of the population dynamics of mutant substitutions.