Darunavir-Loaded Lipid Nanoparticles for Targeting to HIV Reservoirs

Abstract

Darunavir has a low oral bioavailability (37%) due to its lipophilic nature, metabolism by cytochrome P450 enzymes and P-gp efflux. Lipid nanoparticles were prepared in order to overcome its low bioavailability and to increase the binding efficacy of delivery system to the lymphoid system. Darunavir-loaded lipid nanoparticles were prepared using high… (More)
DOI: 10.1208/s12249-017-0876-0

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