Darunavir: a nonpeptidic antiretroviral protease inhibitor.

@article{McCoy2007DarunavirAN,
  title={Darunavir: a nonpeptidic antiretroviral protease inhibitor.},
  author={Christopher M McCoy},
  journal={Clinical therapeutics},
  year={2007},
  volume={29 8},
  pages={
          1559-76
        }
}
BACKGROUND Protease inhibitors were a major therapeutic breakthrough in the mid-1990s for the treatment of HIV infection, which resulted in improved life expectancy for patients who had failed previous therapies. With time and evolution of the virus, however, there is a new population of patients with treatment-resistant disease and few treatment options. Darunavir is a synthetic nonpeptidic analogue of amprenavir with enhanced activity against resistant virus that became available in 2006… Expand
Pharmacologic aspects of new antiretroviral drugs
Pharmacologic aspects of new antiretroviral drugs
Toxicity of HIV protease inhibitors: clinical considerations
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