Darunavir/Ritonavir Pharmacokinetics Following Coadministration With Clarithromycin in Healthy Volunteers

@article{Sekar2008DarunavirRitonavirPF,
  title={Darunavir/Ritonavir Pharmacokinetics Following Coadministration With Clarithromycin in Healthy Volunteers},
  author={Vanitha J. Sekar and Sabrina Spinosa‐Guzman and Els De Paepe and Martine De Pauw and Tony J Vangeneugden and {\'E}ric Lefebvre and Richard M. W. Hoetelmans},
  journal={The Journal of Clinical Pharmacology},
  year={2008},
  volume={48}
}
This study investigated the steady‐state pharmacokinetic interaction between the HIV protease inhibitor, darunavir (TMC114), administered with low‐dose ritonavir (darunavir/ritonavir), and clarithromycin in HIV‐negative healthy volunteers. In a 3‐way crossover study, 18 individuals received darunavir/ritonavir 400/100 mg bid, clarithromycin 500 mg bid, and darunavir/ritonavir 400/100 mg bid plus clarithromycin 500 mg bid in 3 separate sessions for 7 days, with a washout period of at least 7… 

The Effect of Lopinavir/Ritonavir and Darunavir/Ritonavir on the HIV Integrase Inhibitor S/GSK1349572 in Healthy Participants

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Boosted darunavir is an oral nonpeptidic HIV-1 PI that selectively inhibits the cleavage of HIV gag and gag-pol polyproteins, thereby preventing viral maturation and is highly potent against laboratory strains and clinical isolates of wild-type and multidrug-resistant HIV.

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