Dark microglia: A new phenotype predominantly associated with pathological states

@inproceedings{Bisht2016DarkMA,
  title={Dark microglia: A new phenotype predominantly associated with pathological states},
  author={Kanchan Bisht and Kaushik P. Sharma and Cynthia Lecours and Maria Gabriela S{\'a}nchez and Hassan El Hajj and Giampaolo Milior and Adri{\'a}n Olmos‐Alonso and Diego G{\'o}mez‐Nicola and Giamal N. Luheshi and Luc Valli{\`e}res and Igor Branchi and Laura Maggi and Cristina Limatola and Oleg Butovsky and Marie‐{\`E}ve Tremblay},
  booktitle={Glia},
  year={2016}
}
The past decade has witnessed a revolution in our understanding of microglia. These immune cells were shown to actively remodel neuronal circuits, leading to propose new pathogenic mechanisms. To study microglial implication in the loss of synapses, the best pathological correlate of cognitive decline across chronic stress, aging, and diseases, we recently conducted ultrastructural analyses. Our work uncovered the existence of a new microglial phenotype that is rarely present under steady state… CONTINUE READING