Dark matter in the genome: evidence of widespread transcription detected by microarray tiling experiments.

@article{Johnson2005DarkMI,
  title={Dark matter in the genome: evidence of widespread transcription detected by microarray tiling experiments.},
  author={Jason M. Johnson and Stephen Langley Edwards and Daniel Shoemaker and Eric E. Schadt},
  journal={Trends in genetics : TIG},
  year={2005},
  volume={21 2},
  pages={
          93-102
        }
}
Microarrays provide the opportunity to measure transcription from regions of the genome without bias towards the location of known genes. This technology thus offers an important source of genomic sequence annotation that is complementary to cDNA sequencing and computational gene-finding methods. Recent "tiling" microarray experiments that assay transcription at regular intervals throughout the genome have shown evidence of large amounts of transcription outside the boundaries of known genes… CONTINUE READING
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