Daridorexant: First Approval

@article{Markham2022DaridorexantFA,
  title={Daridorexant: First Approval},
  author={Anthony Markham},
  journal={Drugs},
  year={2022},
  volume={82},
  pages={601 - 607}
}
Daridorexant (Quviviq™; Idorsia Pharmaceuticals Ltd.) is an orally administered dual orexin type 1 and type 2 (OX1 and OX2) receptor antagonist (DORA) being developed for the treatment of insomnia. It was selected from a pool of drug candidates on the basis of an expected effect duration of ≈ 8 h at a dose of 25 mg, with a half-life intended to minimize residual effects that might impair daytime functioning. Based on the results of two pivotal phase III trials, daridorexant was recently… 
3 Citations

Daridorexant for the Treatment of Insomnia.

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