Darbepoetin enhances endothelium-dependent vasomotor function in patients with stable coronary artery disease only after preceding ischaemia/reperfusion.

@article{Tilling2012DarbepoetinEE,
  title={Darbepoetin enhances endothelium-dependent vasomotor function in patients with stable coronary artery disease only after preceding ischaemia/reperfusion.},
  author={Lindsey Tilling and Joanne Rachel Hunt and Ann E. Donald and Brian Clapp and Phil Chowienczyk},
  journal={Clinical science},
  year={2012},
  volume={122 7},
  pages={
          329-36
        }
}
Vasoprotective effects of erythropoietin in animal models are mediated by endothelium-derived NO and/or mobilization of EPCs (endothelial progenitor cells) and may be enhanced by ischaemia: whether they are present in humans is unknown. We examined whether the erythropoietin analogue darbepoetin improves FMD (flow-mediated dilatation), a measure of endothelium-derived NO, and whether this is influenced by preceding I/R (ischaemia/reperfusion). A total of 36 patients (50-75 years) with stable… CONTINUE READING

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