Daptomycin versus Vancomycin for Complicated Skin and Skin Structure Infections: Clinical and Economic Outcomes

@article{Davis2007DaptomycinVV,
  title={Daptomycin versus Vancomycin for Complicated Skin and Skin Structure Infections: Clinical and Economic Outcomes},
  author={Susan L. Davis and Peggy S. McKinnon and Levi M. Hall and George Delgado and Warren Rose and Robert F. Wilson and Michael Joseph Rybak},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2007},
  volume={27}
}
  • S. Davis, P. McKinnon, +4 authors M. Rybak
  • Published 1 December 2007
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Study Objective. To assess the effect of daptomycin compared with vancomycin on the clinical and economic outcomes in patients with complicated skin and skin structure infections. 
The efficacy and safety of daptomycin vs. vancomycin for the treatment of cellulitis and erysipelas
TLDR
Daptomycin may result in faster clinical improvement than penicillinase‐resistant penicillins or vancomycin for patients with complicated skin and skin structure infections.
Retrospective review of the use of daptomycin for diabetic foot infections.
TLDR
A retrospective review outlines the clinical outcomes reported for a lipopetide for diabetic foot infections and indicates the need for further research into this drug.
Pharmacological Agents for the Treatment of Skin and Soft Tissue Infections: What is the Role for Daptomycin?
TLDR
Daptomycin has been shown to achieve good concentrations in skin and soft tissues and is effective and safe for the treatment of SSTIs, compared with other antimicrobial agents.
Pilot Study Comparing Daptomycin And Telavancin In The Treatment Of Skin And Soft Tissue Infections
TLDR
There did not appear to be any significant difference in clinical outcomes, rapidity of improvement, adverse events nor relapse rates in patients with lower extremity skin and soft tissue infections treated with daptomycin or telavancin.
Daptomycin Versus Other Antimicrobial Agents for the Treatment of Skin and Soft Tissue Infections: A Meta-Analysis
TLDR
Daptomycin is effective and safe for the treatment of SSTIs and comparisons with new agents, and focusing on proven MRSA S STIs will be helpful for the further evaluation of the drug.
Daptomycin: rationale and role in the management of skin and soft tissue infections.
  • R. Seaton
  • Medicine
    The Journal of antimicrobial chemotherapy
  • 2008
TLDR
Clinical experience to date suggests potential economic advantages associated with earlier hospital discharge and shorter duration of therapy, although further detailed cost-effectiveness comparisons are required to validate these observations in different healthcare settings.
Complicated skin and soft tissue infections: literature review of evidence for and experience with daptomycin
TLDR
A comprehensive review of the evidence for and experience with daptomycin and its use in SSTIs is presented, finding rapid cidality, good soft tissue penetration, once daily IV bolus administration and activity against resistant Gram-positive infections make d aptomycin an attractive option both in hospitalized and community treated patients.
The safety and efficacy of daptomycin versus other antibiotics for skin and soft-tissue infections: a meta-analysis of randomised controlled trials
TLDR
This meta-analysis demonstrated that the safety and efficacy of daptomycin was not inferior to that of other first-line drugs, and d aptomycin tended to exhibit superior efficacy when compared with vancomycin or with comparators for SA infections; nevertheless, more high-quality RCTs are needed to draw a more credible conclusion.
Daptomycin for Treatment of complicated skin and skin structure Infections
TLDR
Daptomycin appears to be a viable alternative to standard treatment options for cSSSI, and the most common side effects were constipation, nausea, and headaches.
An open-label, pragmatic, randomized controlled clinical trial to evaluate the comparative effectiveness of daptomycin versus vancomycin for the treatment of complicated skin and skin structure infection
TLDR
The data suggest that physician and patient preference, rather than drug acquisition cost, should be the primary driver of initial antibiotic selection for hospitalized patients with cSSSI.
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