Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains.

  title={Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains.},
  author={Anna R. M{\"u}ller and Michaela Wenzel and Henrik Strahl and Fabian Grein and Terrens N V Saaki and Bastian Kohl and Tjalling Siersma and Julia E Bandow and H G Sahl and Tanja Schneider and Leendert W Hamoen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 45},
Daptomycin is a highly efficient last-resort antibiotic that targets the bacterial cell membrane. Despite its clinical importance, the exact mechanism by which daptomycin kills bacteria is not fully understood. Different experiments have led to different models, including (i) blockage of cell wall synthesis, (ii) membrane pore formation, and (iii) the generation of altered membrane curvature leading to aberrant recruitment of proteins. To determine which model is correct, we carried out a… CONTINUE READING


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A (2016) Binding of Daptomycin to Anionic Lipid Vesicles Is Reduced in the Presence of Lysyl-Phosphatidylglycerol

TO Khatib, H Stevenson, MR Yeaman, AS Bayer, Pokorny
Antimicrob Agents Chemother • 2016

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