Daptomycin dose-effect relationship against resistant gram-positive organisms.

  title={Daptomycin dose-effect relationship against resistant gram-positive organisms.},
  author={Raymond Cha and Richard G Grucz and Michael Joseph Rybak},
  journal={Antimicrobial agents and chemotherapy},
  volume={47 5},
Daptomycin exhibits in vitro bactericidal activity against clinically significant gram-positive bacteria. We employed pharmacodynamic modeling to determine a once-daily dosing regimen of daptomycin that correlates to pharmacodynamic endpoints for different resistant gram-positive clinical strains. An in vitro pharmacodynamic model with an initial inoculum of 6 log(10) CFU/ml was used to simulate daptomycin regimens ranging in dose from 0 to 9 mg/kg of body weight/day, with corresponding… CONTINUE READING


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