Dapsone-induced severe cutaneous adverse drug reactions are strongly linked with HLA-B*13: 01 allele in the Thai population

  title={Dapsone-induced severe cutaneous adverse drug reactions are strongly linked with HLA-B*13: 01 allele in the Thai population},
  author={T. Tempark and Patompong Satapornpong and P. Rerknimitr and Nontaya Nakkam and Niwat Saksit and P. Wattanakrai and T. Jantararoungtong and N. Koomdee and A. Mahakkanukrauh and W. Tassaneeyakul and Sumitra Suttisai and J. Pratoomwun and J. Klaewsongkram and T. Rerkpattanapipat and C. Sukasem},
  journal={Pharmacogenetics and Genomics},
  • T. Tempark, Patompong Satapornpong, +12 authors C. Sukasem
  • Published 2017
  • Biology, Medicine
  • Pharmacogenetics and Genomics
  • Objectives A previous publication in Chinese leprosy patients showed that the HLA-B*13:01 allele is a strong genetic marker for dapsone-induced drug hypersensitivity reactions, however there are no data describing whether HLA-B*13:01 is a valid marker for prediction of dapsone-induced drug hypersensitivity reactions in other ethnicities or nonleprosy patients. The aim of this study is to investigate whether there is an association between HLA genotypes and dapsone-induced severe cutaneous… CONTINUE READING
    40 Citations
    HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population
    • 4
    • PDF
    Pharmacogenetic Testing for Prevention of Severe Cutaneous Adverse Drug Reactions
    Genetic Diversity of HLA Class I and Class II Alleles in Thai Populations: Contribution to Genotype-Guided Therapeutics
    • 2
    • PDF


    HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
    • S. Hung, Wen-Hung Chung, +16 authors Y. Chen
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2005
    • 694
    • PDF
    HLA-B*13:01 and the dapsone hypersensitivity syndrome.
    • 166
    • PDF
    Candidate HLA genes for prediction of co-trimoxazole-induced severe cutaneous reactions
    • 36
    • PDF
    Association between HLA-B*1301 and dapsone-induced hypersensitivity reactions among leprosy patients in China.
    • 28
    Pharmacogenetics of cutaneous adverse drug reactions
    • M. Aihara
    • Medicine
    • The Journal of dermatology
    • 2011
    • 82