Dapsone in the Management of Acne Vulgaris

@article{Radley2013DapsoneIT,
  title={Dapsone in the Management of Acne Vulgaris},
  author={Kathy Radley and Rod Tucker},
  journal={Journal of the Dermatology Nurses’ Association},
  year={2013},
  volume={5},
  pages={316–319}
}
  • K. Radley, R. Tucker
  • Published 1 November 2013
  • Medicine, Biology
  • Journal of the Dermatology Nurses’ Association
ABSTRACT Dapsone has had a long history of use in medicine dating back to the 1930s although the compound was originally discovered in 1908. The drug has been successfully deployed in the treatment of a range of conditions including leprosy, malaria, dermatitis herpetiformis, tuberculosis, and opportunistic infections such as pneumocystis pneumonia in patients with human immunodeficiency virus. Dapsone possesses both antibacterial and anti-inflammatory properties, and this dual action was… 
Emerging Role of Dapsone in the Management of Acne Vulgaris: Review Article
TLDR
Acne vulgaris can be effectively treated with topical Dapsone, according to clinical trials, and Boolean operators (AND, OR, NOT) had been used to search for articles published in English in 3 databases and peer-reviewed articles.

References

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TLDR
Overall, total systemic exposures to dapsone and its metabolites were approximately 100-fold less for dapone gel than for oral daps one, even in the presence of trimethoprim/ sulfamethoxazole; there were no reports of any haematological adverse events.
Acne fulminans and erythema nodosum during isotretinoin therapy responding to dapsone
TLDR
A patient who developed acne fulminans and erythema nodosum within 3 weeks of starting isotretinoin and then responded to dapsone without oral steroids is reported.
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TLDR
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TLDR
Viewing the randomized clinical trial (RCT) through a military prism will demonstrate how a combat environment combined with the regimentation of the armed forces affected the standard methodology of the RCT.
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TLDR
Dapsone-induced inhibition of both PMN-mediated cytotoxicity and mitogen-stimulated lymphocyte transformation has provided valuable clues to the understanding of the action mode of dapsone as well as new insights into the pathogenesis of certain inflammatory disorders.
Hematologic safety of dapsone gel, 5%, for topical treatment of acne vulgaris.
TLDR
After treatment with dapsone gel, 5%, no clinical or laboratory evidence of drug-induced hemolytic anemia was noted in G6PD-deficient subjects with acne vulgaris.
Clinical evidence for the role of a topical anti-inflammatory agent in comedonal acne: findings from a randomized study of dapsone gel 5% in combination with tazarotene cream 0.1% in patients with acne vulgaris.
TLDR
The results suggest that anti-inflammatory agents such as dapsone can effectively treat early stages of acne (both comedonal and noncomedonal) when used in combination with a retinoid.
Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris.
A comparison of dapsone with 13‐cis retinoic acid in the treatment of nodular cystic acne
TLDR
It is concluded that dapsone is clearly inferior to 13‐cis retinoic acid in the treatment of nodular cystic acne.
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