Dapsone in the Management of Acne Vulgaris

  title={Dapsone in the Management of Acne Vulgaris},
  author={Kathy Radley and Rod Tucker},
  journal={Journal of the Dermatology Nurses’ Association},
  • K. Radley, R. Tucker
  • Published 1 November 2013
  • Medicine, Biology
  • Journal of the Dermatology Nurses’ Association
ABSTRACT Dapsone has had a long history of use in medicine dating back to the 1930s although the compound was originally discovered in 1908. The drug has been successfully deployed in the treatment of a range of conditions including leprosy, malaria, dermatitis herpetiformis, tuberculosis, and opportunistic infections such as pneumocystis pneumonia in patients with human immunodeficiency virus. Dapsone possesses both antibacterial and anti-inflammatory properties, and this dual action was… 

Emerging Role of Dapsone in the Management of Acne Vulgaris: Review Article

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Pharmacokinetics of Dapsone Gel, 5% for the Treatment of Acne Vulgaris

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Acne fulminans and erythema nodosum during isotretinoin therapy responding to dapsone

A patient who developed acne fulminans and erythema nodosum within 3 weeks of starting isotretinoin and then responded to dapsone without oral steroids is reported.

Innovative use of dapsone.

Acne fulminans: explosive systemic form of acne

The disease is destructive, with the acute onset of painful, ulcerative nodules on the face, chest and back, and these acute inflammatory nodules often heal with residual scarring.

A Short History of Dapsone, or an Alternative Model of Drug Development

Viewing the randomized clinical trial (RCT) through a military prism will demonstrate how a combat environment combined with the regimentation of the armed forces affected the standard methodology of the RCT.

Current Aspects of Modes of Action of Dapsone

Dapsone-induced inhibition of both PMN-mediated cytotoxicity and mitogen-stimulated lymphocyte transformation has provided valuable clues to the understanding of the action mode of dapsone as well as new insights into the pathogenesis of certain inflammatory disorders.

Hematologic safety of dapsone gel, 5%, for topical treatment of acne vulgaris.

After treatment with dapsone gel, 5%, no clinical or laboratory evidence of drug-induced hemolytic anemia was noted in G6PD-deficient subjects with acne vulgaris.

Clinical evidence for the role of a topical anti-inflammatory agent in comedonal acne: findings from a randomized study of dapsone gel 5% in combination with tazarotene cream 0.1% in patients with acne vulgaris.

The results suggest that anti-inflammatory agents such as dapsone can effectively treat early stages of acne (both comedonal and noncomedonal) when used in combination with a retinoid.

Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris.

A comparison of dapsone with 13‐cis retinoic acid in the treatment of nodular cystic acne

It is concluded that dapsone is clearly inferior to 13‐cis retinoic acid in the treatment of nodular cystic acne.