Dapsone impairs the bile salt-independent fraction of bile flow in rats: Possible involvement of its N-hydroxylated metabolite.

@article{Veggi2005DapsoneIT,
  title={Dapsone impairs the bile salt-independent fraction of bile flow in rats: Possible involvement of its N-hydroxylated metabolite.},
  author={Luis Mar{\'i}a Veggi and Fernando A. Crocenzi and Marcelo G Roma and Aldo Domingo Mottino},
  journal={Toxicology},
  year={2005},
  volume={211 1-2},
  pages={97-106}
}
The effects of dapsone (DDS) treatment (30 mg/kg body wt, twice a day, for 4 days) on biliary secretory function, with special emphasis on bile salt independent bile flow (BSIF), were investigated in male and in female Wistar rats. Because DDS is metabolized to its N-hydroxylated parent compound only in male rats, any gender difference in DDS effect can be causally attributed to this metabolite. The two main driving forces for BSIF, the biliary secretion of HCO(3)(-) and glutathione species… CONTINUE READING

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