Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus.

@article{Gao2008Dapper1IA,
  title={Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus.},
  author={Xia Gao and Jun Wen and Long Zhang and Xiang Li and Yuanheng Ning and Anming Meng and Ye-Guang Chen},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 51},
  pages={35679-88}
}
Wnt signaling, via the activation of the canonical beta-catenin and lymphoid enhancer factor (LEF)/T-cell factor pathway, plays an important role in embryogenesis and cancer development by regulating the expression of genes involved in cell proliferation, differentiation, and survival. Dapper (Dpr), as a Dishevelled interactor, has been suggested to… CONTINUE READING