Dantrolene protects neurons against kainic acid induced apoptosis in vitro and in vivo.

@article{Popescu2002DantrolenePN,
  title={Dantrolene protects neurons against kainic acid induced apoptosis in vitro and in vivo.},
  author={Bogdan Ovidiu Popescu and M. Oprica and Maria Sajin and Cristina L Stanciu and Ovidiu Băjenaru and Andreea Predescu and Cristina Vidulescu and L M Popescu},
  journal={Journal of cellular and molecular medicine},
  year={2002},
  volume={6 4},
  pages={
          555-69
        }
}
Apoptotic cell death induced by kainic acid (KA) in cultures of rat cerebellar granule cells (CGC) and in different brain regions of Wistar rat pups on postnatal day 21 (P21) was studied. In vitro, KA (100-500 microM) induced a concentration-dependent loss of cell viability in MTT assay and cell death had apoptotic morphology as studied by chromatin staining with propidium iodide (PI). In vivo, twenty-four hours after induction of status epilepticus (SE) by an intraperitoneal KA injection (5 mg… CONTINUE READING

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