Dantrolene is neuroprotective in Huntington's disease transgenic mouse model

@inproceedings{Chen2011DantroleneIN,
  title={Dantrolene is neuroprotective in Huntington's disease transgenic mouse model},
  author={Xiao Dong Chen and Jun Wu and Svetlana Lvovskaya and Emily S Herndon and Charlene Supnet and Ilya B Bezprozvanny},
  booktitle={Molecular Neurodegeneration},
  year={2011}
}
BackgroundHuntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine expansion in the Huntingtin protein which results in the selective degeneration of striatal medium spiny neurons (MSNs). Our group has previously demonstrated that calcium (Ca2+) signaling is abnormal in MSNs from the yeast artificial chromosome transgenic mouse model of HD (YAC128). Moreover, we demonstrated that deranged intracellular Ca2+ signaling sensitizes YAC128 MSNs to glutamate… CONTINUE READING
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