Dantrolene Sodium

  title={Dantrolene Sodium},
  author={Roger Martin Pinder and Rex N. Brogden and Trevor M. Speight and Graeme S. Avery},
SummaryDantrolene sodium or dantrolene1 is 1-[5-(nitrophenyl)furfurylidene] amino hydantoin sodium hydrate. It is indicated for use in chronic disorders characterised by skeletal muscle spasticity, such as spinal cord injury, stroke, cerebral palsy and multiple sclerosis. Dantrolene is believed to act directly on the contractile mechanism of skeletal muscle to decrease the force of contraction in the absence of any demonstrated effects on neural pathways, on the neuromuscular junction, or on… 

Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritis.

Spasticity and Dystonia: A Brief Review

Spasticity and dystonia are two neurological conditions with a broad range of clinical manifestations that can emerge at any age and both of them may cause functional impairment that contributes to a poor quality of life.

Motor Control and Emerging Therapies for Improving Mobility in Patients with Spasticity

New therapies include robot-assisted treadmill training, repetitive electrical stimulation, paired associative stimulation (PAS) and H-reflex conditioning which may provide a new approach for restoring motor function in the spastic patient population.

Diagnosis and treatment of drug-induced hyperthermia.

  • M. MusselmanS. Saely
  • Medicine
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2013
DIH is a hypermetabolic state caused by medications and other agents that alter neurotransmitter levels, and the treatment of DIH syndromes includes supportive care and pharmacotherapy as appropriate.

Oral Medication Use in Cerebral Palsy

The treatment of generalised hypertonia in cerebral palsy with the use of oral medications can be challenging in terms of improvement in patient function and quality of life and evidence for effect is generally limited.

Targeting ryanodine receptors for anti-arrhythmic therapy

This review will evaluate the current pharmacological methods for stabilizing RyR2 and suggest treatment modalities based on current evidence of molecular mechanisms.

Symptomatic treatment and management of multiple sclerosis.

Pharmacologic Treatment Tools: Systemic Medications and Toxins, Opportunities, and Pitfalls.

  • P. RiedelM. Marino
  • Medicine
    Physical medicine and rehabilitation clinics of North America
  • 2018

[Treatment and Management of Spasticity].

In the care of neurological patients with a lesion of the first motor neuron, for example after stroke or multiple sclerosis, spasticity is a common problem with considerable impairment of quality of life.



Site of action of dantrolene in frog sartorius muscle.

Data suggest that dantrolene owes its effect, at least in part, to an inhibition of the "triggering" step in excitation-contraction coupling.

Evaluation of a muscle relaxant: dantrolene sodium (Dantrium).

Dantrolene sodium (Dantrium) is a skeletal muscle relaxant, unique in that it acts on the muscle itself. It should be considered for use in patients with skeletal muscle spasticity who are in a


It is suggested that the EMG test used in this study for the ability to voluntarily control neuromuscular inhibition and activity could be used as an objective experimental procedure for evaluating anti‐spastic drugs.

The effect of dantrolene sodium on spasticity in multiple sclerosis

Clinical studies to date have shown that the drug is effective in patients with severe spasticity resulting from various neurologic disorders, and a doubleblind, crossover trial of dantrolene sodium was carried in a series of patients with multiple sclerosis.

Effect of dantrolene sodium on calcium movements in single muscle fibres

Direct evidence is provided that DaNa interferes with the intracellular movements of calcium ions in skeletal muscle fibres.

Dantrolene effects on neuromuscular function in cat soleus muscle.

  • H. Lowndes
  • Biology, Medicine
    European journal of pharmacology
  • 1975

Effect of dantrolene sodium on excitation-contraction coupling in frog skeletal muscle.

The results suggested that dantrolene acts on the membrane of transverse tubules and possibly the triadic junction and that it inhibits the inward movement of Ca and subsequently decreases the release of activator Ca from sarcoplasmic reticulum.

Studies on the mechanism of action of dantrolene sodium

It is proposed that the muscle relaxant properties of dantrolene sodium are dependent on its direct inhibitory action on skeletal muscle and that this direct action results from an antagonism of calcium release within the muscle.

Dantrolene in Porcine Malignant Hyperthermia

When dantrolene was added to supportive therapy, VO2, lactate, K*, catecholamines, and temperature decreased, and the course of MH was dramatically slowed and, apparently, reversed.