Dantrolene Sodium

@article{Pinder2020DantroleneS,
  title={Dantrolene Sodium},
  author={Roger Martin Pinder and Rex N. Brogden and Trevor M. Speight and Graeme S. Avery},
  journal={Drugs},
  year={2020},
  volume={13},
  pages={3-23}
}
SummaryDantrolene sodium or dantrolene1 is 1-[5-(nitrophenyl)furfurylidene] amino hydantoin sodium hydrate. It is indicated for use in chronic disorders characterised by skeletal muscle spasticity, such as spinal cord injury, stroke, cerebral palsy and multiple sclerosis. Dantrolene is believed to act directly on the contractile mechanism of skeletal muscle to decrease the force of contraction in the absence of any demonstrated effects on neural pathways, on the neuromuscular junction, or on… 

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Dantrolene sodium (Dantrium) is a skeletal muscle relaxant, unique in that it acts on the muscle itself. It should be considered for use in patients with skeletal muscle spasticity who are in a

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Effect of dantrolene sodium on excitation-contraction coupling in frog skeletal muscle.

The results suggested that dantrolene acts on the membrane of transverse tubules and possibly the triadic junction and that it inhibits the inward movement of Ca and subsequently decreases the release of activator Ca from sarcoplasmic reticulum.

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It is proposed that the muscle relaxant properties of dantrolene sodium are dependent on its direct inhibitory action on skeletal muscle and that this direct action results from an antagonism of calcium release within the muscle.

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