Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways.

@article{Chiang2011DanthronAA,
  title={Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways.},
  author={Jo-Hua Chiang and J. Yang and Chia-Yu Ma and Mei-Due Yang and Hui-ying Huang and T. Hsia and H. Kuo and P. Wu and T. Lee and J. Chung},
  journal={Chemical research in toxicology},
  year={2011},
  volume={24 1},
  pages={
          20-9
        }
}
Anthraquinones have been shown to induce apoptosis in different types of tumor cells, but the mechanisms of danthron-induced cytotoxicity and apoptosis in human gastric cancer cells have not been adequately explored. This study investigated the roles of caspase cascades, ROS, DNA damage, mitochondrial disruption, and Bax and Bcl-2 proteins in danthron-induced apoptosis of SNU-1 human gastric cancer cells, a commonly used cell culture system for in vitro studies. Cells were incubated with… Expand
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