Dansyl labeling and bidimensional mass spectrometry to investigate protein carbonylation.

@article{Palmese2011DansylLA,
  title={Dansyl labeling and bidimensional mass spectrometry to investigate protein carbonylation.},
  author={Angelo Palmese and Chiara De Rosa and Gennaro Marino and Angela Amoresano},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2011},
  volume={25 1},
  pages={223-31}
}
Carbonylation is a non-enzymatic irreversible post-translational modification. The adduction of carbonyl groups to proteins is due to the presence of excess of ROS in cells. Carbonylation of specific amino acid side chains is one of the most abundant consequences of oxidative stress; therefore, the determination of carbonyl groups content in proteins is regarded as a reliable way to estimate the cellular damage caused by oxidative stress. This paper reports a novel RIGhT (Reporter Ion… CONTINUE READING

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