Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt/ERK1/2/Nrf2 signaling.

@article{Yu2015DanshensuPI,
  title={Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt/ERK1/2/Nrf2 signaling.},
  author={Jiahui Yu and Lingyan Wang and Mary Akinyi and Yuhong Li and Zhenzhen Duan and Yan Zhu and Guanwei Fan},
  journal={International journal of clinical and experimental medicine},
  year={2015},
  volume={8 9},
  pages={14793-804}
}
Danshen has been widely used in the treatment of cardiovascular diseases while Danshensu [3(3,4dihydroxyphenyl) 2 hydroxy propanoic acid, DSS], a major water-soluble component of Danshen has also been explored as an important compound in Danshen. In the present study, DSS was tested in isolated rat hearts of ischemia reperfusion (I/R) model to investigate its cardioprotective activity and explore the potential molecular mechanism against oxidative stress. The isolated rat hearts were used to… CONTINUE READING